SCHEDULE

We have scheduled our Programs dividing them into Day 1, Day 2, Day 3 in order to make it convenient for you to attend in absolute comfort.

25 Jan
Day 1

Keynote 1

Jung Huang

Saint Louis University School of Medicine ,United States

Title: Intracellular Signaling in Fibrotic Disease

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Abstract:

In ?brotic disease, increased deposition of extracellular matrix (ECM) proteins may alter tissue architecture, and impair normal organ function. Fibrosis is frequently observed in the heart, liver, lungs, and kidneys, but can arise in any other tissues. Currently, no effective agents are available to treat the disease. Transforming growth factorβ (TGF-β), a central mediator of fibrogenesis, is the primary factor that drives fibrosis in most, if not all, forms of the disease. TGF-β appears to be an ideal target for developing anti-fibrotic agents. In our lab, we developed a novel dual TGF-β/IGFBP-3 peptide antagonist which has a very short plasma half-life of <2 min and does not have detectable systemic adverse effects. It effectively blocks TGF-β induction of both the TβR-I/TβRII/Smad2/3/4 canonical and TβR-V/PPase/IRS non-canonical signaling cascades in all cell types studied. The TβR-V/PPase/IRS cascade mediates TGF-β control of cell proliferation in concert with the well-known TβRI/TβR-II/Smad2/3/4 cascade. On the other hand, the TβR-V/PPase/IRS cascade negatively regulates TβR-I/TβRII/Smad2/3/4 cascade-mediated epithelial-to-mesenchymal transition (EMT) frequently observed in invasive carcinoma cells and fibroblasts. These TGF-β signaling cascades cross talk with those mediated by insulin receptor, IGF-1 receptor, integrin and c-Met (hepatocyte growth factor receptor). For example, patients with certain diseases (e.g., diabetes) have more scars and delayed wound healing as compared to normal patients. Our antagonist, which targets both TGF-β signaling cascades, is effective to enhance wound healing and reduce scarring by topical administration in pig skin burn/excision injury models and ameliorates bleomycin-induced lung fibrosis by intranasal administration and CCl4-induced liver fibrosis by liver lymphatic targeting in mice

Keynote 2

Clara Franzini-Armstrong

University of Pennsylvania ,United States
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Biography:

Clara Franzini-Armstrong uses electron microscopy to study skeletal and cardiac muscle on the nanoscopic scale. She is particularly interested in excitation–contraction coupling — the process in muscles by which electrical stimuli are converted into mechanical responses.One of her earliest research milestones was the discovery of the expected opening of transverse tubules at the surface of muscle cells, which allow muscles to be activated to contract. Clara’s subsequent work has revealed much more about how muscle contraction is brought about by means of calcium cycling between the strands of fibres – called myofilaments – and the surrounding, tube-like sarcoplasmic reticulum within muscle cells.Clara has received many awards in recognition of her work, including the K. C. Cole and the Founders Awards of the Biophysical Society in 1989 and 2007, respectively. In addition to being a Foreign Member of the Royal Society, she is also a member of the US National Academy of Sciences and the Accademia Nazionale dei Lincei in Italy.

Keynote 3
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Biography:

Ludger Johannes earned a PhD from Pierre and Marie Curie University, and completed his post-doctoral training in cell biology at Institut Curie, where he currently directs the Cellular and Chemical Biology unit. He has published more than 210 papers on retrograde trafficking and the glycobiology of endocytosis in international journals of repute, such as Cell and Nature. He is serving as an editorial board member for Traffic and PLoS One. He also aims at exploiting his discoveries for the development of innovative immunotherapy strategies against cancer. He is EMBO member since 2012, and currently holds an ERC advanced grant

Abstract:

Several endocytic processes do not require the activity of clathrin, and it has been a major question in membrane biology to know how the plasma membrane is bent and cargo proteins are sorted in these cases. Our previous studies have allowed us to propose the GL-Lect hypothesis: Nanodomain construction by GlycoLipid-binding cellular or pathological Lectins induces membrane curvature changes and drives the formation of tubular endocytic pits from which clathrin-independent carriers are generated for the cellular uptake of glycosylated membrane proteins (CD44, integrins…), pathogens (polyoma viruses, norovirus), or pathogenic factors (Shiga and cholera toxins). We are now analyzing how cortical actin dynamics contributes to the clustering of glycosphingolipid-lectin complexes on active membranes, thereby facilitating the nucleation of endocytic tubules exploiting membrane fluctuation force and asymmetric lipid compaction mechanisms that had not been linked before to endocytosis. Furthermore, we are identifying ways by which the GL-Lect mechanism is acutely controlled by growth factor signaling. Finally, we study how GL-Lect domain construction at the plasma membrane programs the intracellular distribution of cargo proteins via the retrograde transport route, thereby exploiting the polarized secretion capacity of the Golgi apparatus for the distribution of these cargoes to specialized plasma membrane domains in migrating cells (leading edge), epithelial cells (apico-basal sorting and transcytosis), and lymphocytes (immunological synapse). These studies are performed using a combination of cell biological (lattice light sheet microscopy), biochemical (membrane protein purification and reconstitution), and structural biology (cryoEM) techniques on model membranes, in cells, and living organisms. 

Keynote 4

Rosella Mollicone

University Paris Sud-XI ,France
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Biography:

Rosella Mollicone did his PhD at UPMC-Paris-VI. She worked with Rafael Oriol on his FUT1-FUT2 genetic model. She completed her Post-doc with JB Lowe in Ann Arbor, USA. She has published more than 90 papers in international journals, has been an Editorial Board Member, Referee and Opponent for several PhD thesis. She is a full CNRS Research Director since 1997, responsible for the group of fucosyltransferases at INSERM U1197 (Villejuif, France). She works on CDG-type-II and in human ES and IPS cell glycan differentiation. She has received a price for a new human embryonic α3-fucosyltransferase.

Speaker 1

Giovana Aparecida Gonçalves

Centro Universitário Padre Albino-UNIFIP ,Brazil

Title: p27kip1 as a key regulator of endometriosis

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Biography:

Professor of the Padre Albino University Center - UNIFIPA. Assistant Professor of Master's and PhD Degrees by the Department of Gynecology of Federal University of São Paulo - UNIFESP. PhD in Sciences by InCor.HC-FMUSP (2008) and postdoctoral fellow by the Department of Gynecology-UNIFESP (2009-2014) and by the  Laboratory of Angiogenesis and Vascular Metabolism - Vesalius Research Center / KULeuven-Leuven / Belgium under the supervision of Prof. Peter Carmeliet (2014-2015). Develops projects in the area of Gene Therapy and Cell Therapy as a focus in angiogenesis. 

Abstract:

p27kip1 is a cyclin-dependent kinase (CDK) inhibitor whose specific late G1 destruction allows progression of the cell across the G1/S boundary. There is a direct relationship between low level of p27 and rapid proliferation occurring in several benign states and in many malignances. In the glandular cells of the normal endometrium, the level of p27kip1 is exceedingly low during the proliferative phase, whereas it is markedly increased during the secretory phase. The expression of p27kip1 in endometriosis is very low but has been found to increase following treatment with progesterone. However, estrogen exposure is considered as a major risk factor in developing endometrial cancer. Endometriosis endometrial cells cultures have also lower levels of p27kip1 compared to heath endometrial cells cultures and restore the cell cycle balance when transduced with an adenoviral vector carring the p27kip1 coding gene (Adp27EGFP). More uniform and rigorous studies are required to confirm these and additional markers utility in a diagnostic and possible treatment panel. As a major clinical priority is to determine which lesions can be treated medically and which require surgical intervention, focusing future studies on markers that distinguish response to hormone therapy or are involved in hormone regulation, will be important future considerations. The goal of this highlight review is to provide a broad overview of the advancements in studies about endometriosis mainly correlating the cytokine p27kip1 expression with the diagnostic and disease treatment

Speaker 2
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Biography:

Dr. Anna Landsman is a lecturer and researcher in the Lev Academic Center of Jerusalem. She He received a bachelor’s degree in  Dnipropetrovsk State Medical Academy (Ukraine), a master’s degree in and PhD degree in Human Physiology from Hebrew University in Jerusalem, Israel. She complited a postdoctoral fellowship in Hadassah Medical Center, Jerusalem. Her research interests include human physiology, molecular mechanism underlines psychiatric disorders, gene therapy approach for cancer treatment

Abstract:

Postpartum depression (PPD) is a disease which incorporates a variety of depressive states differing in nature and severity. To assist in the understanding of the pathogenesis of the disease, we aimed to ascertain a molecular mechanism underlying PPD development. We applied microarray technology to characterize gene expression of euthymic women with a history of PPD and compared the results with healthy controls. Our study demonstrated that women who considered euthymic on a clinical level, in fact, had an altered molecular profile when compared to participants with no PPD history. We identified nine genes significantly distinguished expression in post-depressive women; they may serve as a diagnostic tool for the detection of a predisposition to PPD.  Our findings contribute significantly to the understanding of PPD etiology and its pathogenesis, offer a plausible explanation for the risk of the PPD recurrence, and may also contribute to clinical treatment.

Speaker 3
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Biography:

Dr. Anna Cornelia Beyer is Senior Lecturer at the University of Hull. She has published 7 monographs and about 30 articles on war and terrorism, their causes and how to prevent them. Recently, she has published a self-help book for schizophrenia, entitled Health and Safety for Spirit Seers, Telepaths and Visionaries – Self-help for Schizophrenia

Abstract:

Schizophrenia is a debilitating illness that includes the main symptom of voice hearing and delusions, which can become as painful as strong physical pain and very frightening. Many patients with this illness live on disability income, unemployment and suicide are high, life expectancy is 15 years reduced. From a patients perspective, and from the perspective as a scientist, this paper will describe a holistic treatment approach that might work better than reliance on medication alone. It will describe the use of vitamin therapy, a healthy lifestyle, and spirituality. It will also point out the role of caffeine and nicotine abuse for contributing to the symptoms of schizophrenia.